Diabetes/metabolism research and reviews
The most recent articles from:
October 2008
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Diabetes Metab. Res. Rev. · Oct 2008
Plasma glycooxidation protein products in type 2 diabetic patients with nephropathy.
In diabetes mellitus, hyperglycaemia accelerates non-enzymatic glycation and oxidative stress leading to damage of macromolecules, among others proteins. This manifests in the increased levels of advanced glycation end products (AGE) and advanced oxidation protein products (AOPP). ⋯ The connection between plasma levels of both glycooxidation protein products-AGE and AOPP with nephropathy severity, measured by the degree of albuminuria, in T2DM patients was observed. We can suggest that the AOPP better reflect the progression of kidney damage than AGE in examined diabetic patients.