Pharmacology & toxicology
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Pharmacology & toxicology · Dec 1997
Randomized Controlled Trial Clinical TrialPostoperative recovery after cholecystectomy by minilaparotomy: a randomized double-blind comparison between alpha-trinositol and placebo.
An opioid-sparing effect of alpha-trinositol (D-myo-inositol 1,2,6-trisphosphate) following cholecystectomy in otherwise healthy patients was suggested by a pilot study. In order to verify this result, pain, pain relief and nausea were studied in patients undergoing elective cholecystectomy by minilaparotomy. The patients were randomized using double-blind design to receive an intravenous infusion of either alpha-trinositol or sodium chloride (placebo) for eight hr after the operation. ⋯ Neither pressure pain thresholds, nor the walking distance differed between the patients given alpha-trinositol and placebo, respectively. There were significant reductions of peak expiratory flow and of pressure pain thresholds under both costal margins up to 72 hr after surgery compared to presurgery values. As a conclusion, no analgesic effect of alpha-trinositol at the dosage used was observed in the postoperative patients studied.
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Pharmacology & toxicology · May 1991
Randomized Controlled Trial Clinical Trial Controlled Clinical TrialAssessment of the sedative effects of dexmedetomidine, an alpha 2-adrenoceptor agonist, with analysis of saccadic eye movements.
Single intravenous doses (0.5 microgram/kg and 1.0 microgram kg) of dexmedetomidine (4(5)-(1-(2,3-dimethylphenyl)ethyl)imidazole), a selective alpha 2-adrenoceptor agonist, and saline placebo were administered to six healthy volunteers (4 males and 2 females) in a double-blind, placebo-controlled cross-over study. The effects on vigilance were assessed using both subjective estimation (visual analogue scale, VAS) and objective tests (critical flicker fusion frequency, CFF; the Maddox wing; saccadic eye movement analysis). ⋯ The changes in vigilance were concurrent with moderate reductions in blood pressure and heart rate. CFF, the Maddox wing and peak saccadic velocity all proved sensitive in the assessment of sedation induced by dexmedetomidine.