Diabetes, obesity & metabolism
The most recent articles from:
March 2011
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Diabetes Obes Metab · Mar 2011
Meta AnalysisEffect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials.
Some studies suggested that metformin could reduce cardiovascular risk to a greater extent than that determined by glucose reduction. Aim of the present meta-analysis is to assess the effects of metformin on the incidence of cardiovascular events and mortality. ⋯ Available evidence seems to exclude any overall harmful effect of metformin on cardiovascular risk, suggesting a possible benefit versus placebo/no treatment. The observed detrimental effect of the combination with sulphonylureas deserves further investigation.