Pediatric research
-
Randomized Controlled Trial
Phase 1 study of two inodilators in neonates undergoing cardiovascular surgery.
Inodilators are routinely used in cardiovascular surgery with cardiopulmonary bypass (CPB). Information regarding safety and tolerability of the novel molecule, levosimendan (LEVO), in newborns is anecdotal; no pharmacokinetic data in this population are available. ⋯ LEVO is well tolerated in critically ill neonates. LEVO may have advantages over MR in terms of the dosing regimen.
-
Randomized Controlled Trial Comparative Study
Premedication for intubation with morphine causes prolonged depression of electrocortical background activity in preterm infants.
Sedative and analgesic medications are used in critically ill newborns, but little is known about their effects on electrocortical activity in preterm infants. We hypothesized that morphine might induce prolonged neurodepression, independent of blood pressure, as compared with rapid sequence induction/intubation(RSI). ⋯ Premedication with morphine is associated with prolonged aEEG/EEG depression independent of blood pressure changes and may not be optimal for short procedures.