European journal of heart failure
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Eur. J. Heart Fail. · Apr 2012
Review Meta AnalysisIron supplementation for the treatment of chronic heart failure and iron deficiency: systematic review and meta-analysis.
Over half of chronic heart failure (CHF) patients are anaemic, and iron deficiency is common. Iron replacement therapy (oral or i.v.) might improve exercise capacity and quality of life (QOL). ⋯ Intravenous iron therapy is associated with improved QOL parameters, reduction in hospitalizations, and increased 6MWD. Treatment with i.v. iron is safe, with no increased rate of adverse events. The results of our analysis are limited by the paucity of trials, and significant heterogeneity between trials.