Deutsche medizinische Wochenschrift
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Dtsch. Med. Wochenschr. · Oct 2007
Multicenter Study[Liposomal amphotericin B in the treatment of severe fungal infections. Results of a clinical cohort trial].
Activity and efficacy of liposomal amphotericin B have been established for the treatment of severe fungal infections. Nephrotoxic side effects, especially during prolonged administration, are regarded as a major disadvantage. In this study we examined the response rates and side effects, particularly nephrotoxicity, of treatment with liposomal amphotericin B in a large cohort of patients. ⋯ Liposomal amphotericin B is a safe and efficacious antifungal drug in the treatment of severe invasive fungal infections and fever of unknown origin. Nephrotoxicity is usually not a limiting factor when using liposomal amphotericin B, if it is administered in approved dosage.