European journal of nutrition
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Randomized Controlled Trial Comparative Study Clinical Trial
Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects.
The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO). ⋯ The data presented suggest that γ-cyclodextrin curcumin formulation (CW8) significantly improves the absorption of curcuminoids in healthy humans.
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Randomized Controlled Trial
Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial.
As populations shift to include a larger proportion of older adults, the necessity of research targeting older populations is becoming increasingly apparent. Dietary interventions with blueberry have been associated with positive outcomes in cell and rodent models of aging. We hypothesized that dietary blueberry would improve mobility and cognition among older adults. ⋯ These findings show that the addition of easily achievable quantities of blueberry to the diets of older adults can improve some aspects of cognition.