Antioxidants & redox signaling
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Antioxid. Redox Signal. · Aug 2011
Redox regulation of the influenza hemagglutinin maturation process: a new cell-mediated strategy for anti-influenza therapy.
The aim of this study was to determine whether GSH-C4, a hydrophobic glutathione derivative, affects in vitro and in vivo influenza virus infection by interfering with redox-sensitive intracellular pathways involved in the maturation of viral hemagglutinin (HA). ⋯ Redox-sensitive host-cell pathways exploited for viral replication are promising targets for effective anti-influenza strategies.