Diabetes technology & therapeutics
-
Diabetes Technol. Ther. · Feb 2011
Randomized Controlled Trial Multicenter Study Comparative StudyConversion from intravenous insulin to subcutaneous insulin after cardiovascular surgery: transition to target study.
No study of transition from intravenous to subcutaneous insulin after cardiac surgery with dose based on percentage of intravenous total daily insulin (TDI) has reported a clearly superior regimen for achieving target blood glucose. We compared three first-dose transition strategies for insulin glargine: two based on TDI alone and one that also took body weight into account. ⋯ No subcutaneous insulin regimen implemented approximately 1 day after cardiac surgery showed significantly better control of blood glucose over the 3-day study period. Further studies are needed to determine optimal formulae for effecting an early transition to subcutaneous insulin after cardiac surgery or whether it is preferable and/or necessary to continue intravenous insulin therapy for an additional period of time.