Respiration physiology
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Respiration physiology · Aug 2001
Airway ammonia negates the normal ventilatory response to airway CO(2) in garter snakes.
Earlier studies from this lab showed that unidirectionally ventilated snakes, maintained on high airway [CO(2)], breathe slowly with a large tidal volume. If airway [CO(2)] is abruptly reduced during inspiration, inspiratory duration (TI) and tidal volume increase. On the other hand, in an animal normally receiving fresh air (no CO(2) in the inspired air) on each inspiration, if fresh air is withheld for one breath, TI and tidal volume decrease. ⋯ However, for one breath, [CO(2)] was maintained high during inspiration and airway NH(3) (3--4%) was simultaneously introduced into the airstream. During this breath, TI was expected to decrease, owing to the elevated [CO(2)]; however, there was no significant difference in the TI of the test breath compared with the previous breath, indicating that ammonia interfered with the expected CO(2) response. This study suggests that pH (probably intracellular) rather than P(CO(2)) produces this ventilatory reflex.