Reumatismo
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Randomized Controlled Trial Comparative Study
Efficacy and safety of two generic copies of nimesulide in patients with low back pain or knee osteoarthritis.
Two generic bioequivalent copies of the same drug sometimes do not achieve therapeutic equivalence. This may produce adverse events in clinical practice if the therapeutic index of that drug is narrow. ⋯ T and N are equally effective and safe forms of nimesulide for pain management in low back pain and knee osteoarthritis. Price per daily dose is a relevant parameter for making a choice. However, regulations regarding drug bioequivalence criteria should be met for drug marketing authorization submission.