Polish journal of pharmacology
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Experimental data indicate that nitric oxide (NO) may play a role in the pathophysiology of epilepsy. It is also possible that NO-mediated events are involved in the expression of the anticonvulsant action of some antiepileptics. ⋯ The influence of various NO synthase inhibitors (NOSI) on antiseizure activity of AEDs was tested in many animal experimental models of epilepsy (electrically and pharmacologically evoked seizures, sound-induced convulsions, amygdala-kindled seizures). Although some NOSI were able to modify the anticonvulsive properties of AEDs, the involvement of NO pathway in the mechanisms of action of AEDs in most cases does not seem probable, since the effects of NOSI were not reversed by L-arginine, a NO precursor.