Pain medicine : the official journal of the American Academy of Pain Medicine
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Randomized Controlled Trial
Women with pain due to osteoarthritis: the efficacy and safety of a once-daily formulation of tramadol.
This analysis assesses the efficacy and safety of treatment with a once-daily oral formulation of tramadol for up to 12 weeks compared with placebo in women with moderate-to-severe pain due to osteoarthritis of the knee. ⋯ For moderate-to-severe pain due to osteoarthritis of the knee, women experience significant analgesia and improvement of physical function over time with treatment with Tramadol Contramid OAD.
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Randomized Controlled Trial
Intranasal ketorolac for postoperative pain: a phase 3, double-blind, randomized study.
Analgesic efficacy and tolerability of intranasal (IN) ketorolac was evaluated in postoperative patients in a randomized, double-blind, placebo-controlled study. ⋯ IN ketorolac was well tolerated and effective in treating moderate-to-severe postoperative pain in inpatients; the convenience of IN dosing suggests that its usefulness in the ambulatory care setting should be evaluated.
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Randomized Controlled Trial
Botulinum neurotoxin-A for treatment of refractory neck pain: a randomized, double-blind study.
To investigate the efficacy and tolerability of Botulinum neurotoxin-A (BoNT-A) in the patients with refractory neck pain. ⋯ Administration of BoNT-A into the neck and shoulder muscles for treatment of chronic refractory neck pain met one of the two primary outcomes: reduction in pain intensity. More ERs were noted in the Botox group.