Pain medicine : the official journal of the American Academy of Pain Medicine
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To determine the risk: benefit of paracetamol combined with caffeine in the short-term management of acute pain conditions. ⋯ Paracetamol/caffeine (1,000 mg/130 mg) is effective and safe for use in acute management of pain. The hepatotoxicity of overdoses of paracetamol results from its oxidative metabolism, caffeine does not produce any increase in oxidative metabolism of therapeutic concentrations of paracetamol.