Pain medicine : the official journal of the American Academy of Pain Medicine
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This two-sample Mendelian randomization study examined causal associations of C-reactive protein (CRP) with spinal pain, the extent of multisite chronic pain, and chronic widespread musculoskeletal pain. No causal associations were found between CRP and these pain conditions.
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To compare localized (primary) and widespread (secondary) hyperalgesia using pressure pain threshold (PPT) of patients with normal imaging findings, rotator cuff tear, or other pathologies. ⋯ No significant difference was observed in the analysis of ipsilateral deltoid or contralateral TA PPT between patients with differing structural shoulder pathologies. These findings suggest that the three types of structural shoulder abnormalities we examined are not significantly associated with differences in one measure of hyperalgesia.
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Tapering of chronic opioids has increased, with subsequent reports of exacerbated pain among patients who tapered. We aimed to evaluate the association between opioid dose tapering and subsequent pain-related healthcare utilization (ED visits, hospitalizations and primary care visits). ⋯ These associations suggest that opioid tapering may lead to increased emergency and hospital utilization for acute pain and possibly a decreased perceived need for primary care for those whose opioids were discontinued.
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Fibromyalgia, which is becoming increasingly common today, affects the quality of life of those affected. The aim of this study was to investigate the relationship between diet and pain, disease severity and biochemical parameters in fibromyalgia. ⋯ A pro-inflammatory diet was associated with higher pain, disease severity and uric acid/creatinine ratio in patients with FM.