São Paulo medical journal = Revista paulista de medicina
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Randomized Controlled Trial Comparative Study Clinical Trial
Antidepressant efficacy of sertraline and imipramine for the treatment of major depression in elderly outpatients.
Most double-blind studies of efficacy and tolerability of sertraline as compared to tricyclics in the treatment of late-life major depression have used amitriptyline as a standard, leading to the inevitable conclusion that the former drug is better tolerated than the latter, with both being equally efficacious. ⋯ Both sertraline and imipramine exhibited good efficacy and an acceptable side-effect profile for elderly depressed patients after 6 weeks of antidepressant treatment.