Pharmacogenomics
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Randomized Controlled Trial
Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype.
Determine whether SNPs of OPRM1 118A>G (asn(40)asp), COMT 472G>A (val(158)met) and ARRB2 8622C>T are associated with morphine rescue in newborns on mechanical ventilation. ⋯ Combined OPRM1 118A>G and COMT 472G>A genotype might serve as a predictor for the need of rescue morphine in premature and term newborns on mechanical ventilation.