Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University
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Hunan Yi Ke Da Xue Xue Bao · Feb 2001
[Protective effects of sevoflurane pretreatment on myocardial ischemia-reperfusion injury in rabbits].
To observe the myocardial protective effects of sevoflurane pretreatment on ischemia-reperfusion injury, forty eight rabbits were divided into six groups randomly: control group, ischemia-preconditioning group, sevoflurane preconditioning group, ischemia preconditioning plus glyburide group, sevoflurane preconditioning plus glyburide group, glyburide group, each group subjected to three hours of left anterion descending coronary artery occlusion followed by three hours of reperfusion. Infarct size and area at risk were defined by staining. ⋯ Glyburide alone did not increase infarct size [IS:AR = (63.2 +/- 12.5)%, not significant]. It suggests that sevoflurane pretreatment protects the rabbit heart subjected to three hours of coronary occlusion from infarction.