Sleep medicine
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Randomized Controlled Trial Multicenter Study
Efficacy and safety of zolpidem-MR: a double-blind, placebo-controlled study in adults with primary insomnia.
To evaluate the clinical efficacy and safety of modified-release zolpidem (zolpidem-MR 12.5mg) for the treatment of primary insomnia in adults. ⋯ Zolpidem-MR 12.5mg is effective and safe in treating primary insomnia in adults and improves sleep maintenance, induction and duration of sleep.
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Randomized Controlled Trial
Efficacy and safety of pramipexole in idiopathic restless legs syndrome: a polysomnographic dose-finding study--the PRELUDE study.
To evaluate the effects of pramipexole (0.125-0.75 mg/d) on polysomnographic (PSG) measures and patient and clinician ratings of restless legs syndrome (RLS). ⋯ Pramipexole is effective and safe in the treatment of both objective and subjective facets of RLS.