Sleep medicine
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Randomized Controlled Trial
Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome.
Depression is a common problem in patients with Delayed Sleep Phase Syndrome (DSPS). This study used a randomized, double-blind, crossover, placebo-controlled approach to test the hypothesis that exogenous melatonin (5mg) can attenuate depressive symptomatology in DSPS patients. ⋯ Exogenous melatonin treatment may be an effective treatment modality for individuals with circadian rhythm sleep disorders and associated comorbid depressive symptomatology.
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Randomized Controlled Trial
Residual sleep apnea on polysomnography after 3 months of CPAP therapy: clinical implications, predictors and patterns.
We sought to determine the clinical implications, predictors and patterns of residual sleep apnea on continuous positive airway pressure (CPAP) treatment in patients with moderate-to-severe obstructive sleep apnea (OSA). ⋯ Residual sleep apnea is common in patients with moderate-to-severe OSA, despite careful CPAP titration, and is associated with worse outcomes.