High altitude medicine & biology
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High Alt. Med. Biol. · Mar 2021
Altitude, Acute Mountain Sickness, and Acetazolamide: Recommendations for Rapid Ascent.
Toussaint, Claudia M., Robert W. Kenefick, Frank A. Petrassi, Stephen R. ⋯ We included only research articles/studies that focused on evaluation of AZ use during rapid ascent. Results: Four doses of AZ (125, 250, 500, and 750 mg daily) were identified as efficacious in decreasing the incidence and/or severity of AMS during rapid ascents, with evidence of enhanced effectiveness with higher doses. Conclusions: For military, emergency medical, or other activities involving rapid ascent to altitudes >3,500 m, doses 500-750 mg/day within 24 hours of altitude exposure appear to be the most effective for minimizing symptoms of AMS.