American journal of physiology. Gastrointestinal and liver physiology
-
Am. J. Physiol. Gastrointest. Liver Physiol. · Aug 2004
Randomized Controlled Trial Clinical TrialEffect of oral CCK-1 agonist GI181771X on fasting and postprandial gastric functions in healthy volunteers.
CCK influences satiation and gastric and gallbladder emptying. GI181771X is a novel oral CCK-1 agonist; its effects on gastric emptying of solids, accommodation, and postprandial symptoms are unclear. Effects of four dose levels of the oral CCK-1 agonist GI181771X and placebo on gastric functions and postprandial symptoms were compared in 61 healthy men and women in a randomized, gender-stratified, double-blind, double-dummy placebo-controlled, parallel group study. ⋯ Adverse effects were predominantly gastrointestinal and occurred in a minority of participants. GI181771X delays gastric emptying of solids and exhibits an acceptable safety profile in healthy participants. CCK-1 receptors can be modulated to increase fasting gastric volume.