Molecular genetics & genomic medicine
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Mol Genet Genomic Med · Feb 2020
Review Meta AnalysisDiagnostic accuracy of midkine for hepatocellular carcinoma: A meta-analysis.
There have been many reports on midkine as a promising marker in the diagnosis of hepatocellular carcinoma (HCC). However, the results are inconsistent and even conflicting. ⋯ Midkine has moderate diagnostic accuracy for HCC. Due to the design limitations, results inpublished studies should be carefully interpreted. In addition, more well-designed studies with large sample sizes should be performed to rigorously evaluate the diagnostic accuracy of the MDK.