Current opinion in allergy and clinical immunology
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Curr Opin Allergy Clin Immunol · Apr 2015
ReviewAirway molecular endotypes of asthma: dissecting the heterogeneity.
This review will cover advances over the past year in defining airway endotypes in asthma by gene expression and the relationship between these endotypes and clinical traits. ⋯ Molecular endotyping of asthmatic patients using gene expression profiling of airway samples is helping to uncover disease mechanisms and potential novel treatment targets. The advancement of endotyping methods holds the promise of future personalized treatment for asthma.
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Curr Opin Allergy Clin Immunol · Apr 2015
ReviewChildhood asthma and chronic obstructive pulmonary disease: outcomes until the age of 50.
There has been recent interest in understanding the origins of chronic obstructive pulmonary disease. Epidemiological studies suggest that chronic obstructive pulmonary disease clearly has other causes apart from tobacco smoke. ⋯ Children with severe asthma are at increased risk of developing chronic obstructive pulmonary disease.