Current opinion in allergy and clinical immunology
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Curr Opin Allergy Clin Immunol · Dec 2014
ReviewWhen less is more: primary immunodeficiency with an autoinflammatory kick.
Next-generation sequencing is revolutionizing the molecular taxonomy of human disease. Recent studies of patients with unexplained autoinflammatory disorders reveal germline genetic mutations that target important regulators of innate immunity. ⋯ These findings underscore the power of next-generation sequencing, demonstrating how the primary deficiency of key molecular regulators or even regulatory motifs may lead to autoinflammation, and suggesting a possible role for cat eye syndrome chromosome region, candidate 1 and phospholipase Cγ₂ in common diseases.
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Curr Opin Allergy Clin Immunol · Dec 2014
ReviewSublingual immunotherapy in children: the recent experiences.
Sublingual immunotherapy (SLIT) is indicated for the use in pediatric patients suffering from allergic rhinitis or allergic rhinoconjunctivitis caused by environmental allergens, such as ragweed pollen, grass pollen, and dust mite. This review focuses on recent and relevant studies associated with the use of SLIT for these allergens in children by examining efficacy, safety, and immunological data in comparison to subcutaneous immunotherapy, therapeutic treatments, and placebo. ⋯ SLIT treatment is a well tolerated and effective approach to treat allergic rhinitis and allergic rhinoconjunctivitis in pediatric patients. Three SLIT tablets are currently approved by the US Food and Drug Administration to treat grass and ragweed allergies. The research discussed in this review will further the knowledge of physicians searching for an alternative treatment for their pediatric patients.
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Curr Opin Allergy Clin Immunol · Dec 2014
ReviewImmunological mechanisms of sublingual immunotherapy.
This review aims to recap recent published data on immunological mechanisms underlying sublingual immunotherapy (SLIT). ⋯ Altogether, exiting data have been published providing a better understanding of immunological features of SLIT but far more basic research is necessary to further uncover key mechanisms of SLIT.
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Curr Opin Allergy Clin Immunol · Jun 2014
ReviewDifferential diagnosis of food protein-induced enterocolitis syndrome.
To assess all the possible differential diagnosis of food protein-induced enterocolitis syndrome (FPIES), both in acute and chronic presentation, reviewing the data reported in published studies. ⋯ A thorough clinical evaluation, including symptoms, signs, and laboratory findings, is necessary to lead the clinicians toward the diagnosis of FPIES. The major reason for delayed diagnosis appears to be the lack of knowledge of the disease.
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Curr Opin Allergy Clin Immunol · Apr 2014
ReviewShared clinician-patient decision-making about treatment of pediatric asthma: what do we know and how can we use it?
Shared decision-making (SDM) is an emerging field that promises to improve healthcare. We aim to explore the concept of SDM, how it has been studied or applied in the treatment of asthma, and how it might be implemented to improve adherence and outcomes in pediatric asthma. ⋯ SDM has the promise to improve satisfaction with disease management, treatment adherence and patient-centered outcomes in pediatric asthma, but further research is needed to determine its effectiveness and to establish guidelines on how to implement SDM in the clinical setting and incorporate the input and preferences of all stakeholders' perspectives.