Nature communications
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The original version of this Article contained an error in the third sentence of the first paragraph of the 'Spin polarizing the Sr+ ion with ultracold atoms' section of the Results, which incorrectly read 'The Langevin collision rate is 1.' The correct version adds 'kHz' after '1.' The fifth sentence of this same paragraph originally read as "Although 87Rb has a I = 3/2 nuclear spin and a hyperfine-split ground-state manifold, 88Sr has no nuclear spin and a Zeeman split two-fold ground state", which is incorrect. The correct version states "88Sr+" instead of "88Sr". ⋯ In the Discussion section, the text was originally incorrectly repeated. This has been corrected in both the PDF and HTML versions of the Article.
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Nature communications · Apr 2018
Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.
Deregulation of the phosphoinositide 3-kinase (PI3K) pathway contributes to the development and progression of tumors. Here, we determine that somatic mutations in PIK3CA (44%), PIK3R1 (17%), AKT3 (15%), and PTEN (12%) are prevalent and diverse in Chinese breast cancer patients, with 60 novel mutations identified. A high proportion of tumors harbors multiple mutations, especially PIK3CA plus PIK3R1 mutations (9.0%). ⋯ These PIK3CA and PIK3R1 impactful mutations exhibit a mutually exclusive pattern, leading to oncogenesis and hyperactivity of PI3K pathway. The PIK3CA impactful mutations are tightly associated with hormone receptor positivity. Collectively, these findings advance our understanding of PI3K impactful mutations in breast cancer and have important implications for PI3K-targeted therapy in precision oncology.