The journal of headache and pain
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Randomized Controlled Trial
The impact of fremanezumab on medication overuse in patients with chronic migraine: subgroup analysis of the HALO CM study.
We evaluated the efficacy of fremanezumab, a fully humanized monoclonal antibody that selectively targets calcitonin gene-related peptide, in patients with chronic migraine (CM) with and without medication overuse (MO). ⋯ Fremanezumab is effective for prevention of migraine in patients with CM, regardless of MO, and demonstrated a benefit over placebo in reducing MO.