The journal of headache and pain
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Review Meta Analysis
Prediction models for treatment response in migraine: a systematic review and meta-analysis.
Migraine is a complex neurological disorder with significant clinical variability, posing challenges for effective management. Multiple treatments are available for migraine, but individual responses vary widely, making accurate prediction crucial for personalized care. This study aims to examine the use of statistical and machine learning models to predict treatment response in migraine patients. ⋯ This review highlights the potential of statistical and machine learning models in predicting treatment response in migraine patients. However, the high risk of bias and significant heterogeneity emphasize the need for caution in interpretation. Future research should focus on developing models using high-quality, comprehensive, and multicenter datasets, rigorous external validation, and adherence to standardized guidelines like TRIPOD + AI. Incorporating multimodal magnetic resonance imaging (MRI) data, exploring migraine symptom-treatment interactions, and establishing uniform methodologies for outcome measures, sample size calculations, and missing data handling will enhance model reliability and clinical applicability, ultimately improving patient outcomes and reducing healthcare burdens.
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Review Meta Analysis
Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis.
Statins or 3‑hydroxy‑3‑methyl‑glutarylcoenzyme A (HMG‑CoA) reductase inhibitors are medications that act by reducing the cholesterol content of liver cells Moreover, statins have been found to improve endothelial function and reduce vascular wall inflammation. A growing body of research suggests that statins are associated with less risk of migraine, and they can be used to treat symptoms. However, the evidence has been inconclusive, so we aim to investigate the nature and strength of the effect of statins on the prevention and prophylaxis of migraines. ⋯ Statins, already well-established for cardiovascular benefits, emerge as a promising dual-purpose therapy for many neurological disorders. The association between the HMGCR gene and increased migraine risk, coupled with the possible efficacy of statins in reducing migraine frequency, may open new avenues for migraine prophylaxis. However, the variability in study design hinders definitive conclusions, so larger studies with longer follow-ups are required to ascertain both findings.