Veterinary anaesthesia and analgesia
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Randomized Controlled Trial Comparative Study
Post-operative analgesic effects of butorphanol or firocoxib administered to dogs undergoing elective ovariohysterectomy.
To compare the post-operative analgesic effects of butorphanol or firocoxib in dogs undergoing ovariohysterectomy. ⋯ Firocoxib produced better post-operative analgesia than butorphanol. Firocoxib may be used as part of a multimodal analgesia protocol but may not be effective as a sole analgesic.
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Randomized Controlled Trial
The effect of midazolam on the end-tidal concentration of isoflurane necessary to prevent movement in dogs.
To determine the possible additive effect of midazolam, a GABA(A) agonist, on the end-tidal concentration of isoflurane that prevents movement (MAC(NM) ) in response to noxious stimulation. ⋯ Midazolam doses in the range of 10-80 μg kg(-1) minute(-1) significantly reduced the isoflurane MAC(NM) . However, doses greater than 10 μg kg(-1) minute(-1) did not further decrease MAC(NM) indicating a ceiling effect.
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Randomized Controlled Trial Comparative Study
A comparison of epidural morphine with low dose bupivacaine versus epidural morphine alone on motor and respiratory function in dogs following splenectomy.
To compare post-operative motor function in dogs that received epidural morphine and low dose bupivacaine versus epidural morphine alone following splenectomy. ⋯ The combination of low dose bupivacaine (0.25 mg kg(-1)) and morphine (0.1 mg kg(-1)) when administered epidurally has little effect on post-operative motor function. This combination can be used without concern of motor paralysis in healthy animals.