Scandinavian journal of thoracic and cardiovascular surgery
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Scand J Thorac Cardiovasc Surg · Jan 1977
Randomized Controlled Trial Clinical TrialModerate and extreme haemodilution in open-heart surgery. Blood requirements, bleeding and platelet counts.
Requirements of donor blood, bleeding and platelet counts were investigated during moderate and extreme haemodilution in patients undergoing aortic valve replecement. A preliminary study of 60 patients, divided in two groups of 30 patients each, was first made. A moderate haemodilution was used in one group and an extreme haemodilution with the aid of autologous transfusion was utilized in the other. ⋯ The circulating platelet counts fell less during and after the operation in this group than in the moderately diluted patients. After adjustment for the dilution, the platelet counts fell to about 60% in the moderate dilution group during the perfusion, but rose to about 130% in the extremely diluted patients. These findings are discussed.