The lancet oncology
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The lancet oncology · Jun 2012
Review Comparative StudyLenalidomide maintenance for multiple myeloma.
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The lancet oncology · Jun 2012
Randomized Controlled Trial Multicenter Study Comparative StudyChemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial.
Fluorouracil-based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. We investigated the efficacy and safety of substituting fluorouracil with the oral prodrug capecitabine. ⋯ Roche Pharma AG (Grenzach-Wyhlen, Germany).
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Since the identification of microRNAs (miRNAs) in 1993, and the subsequent discovery of their highly conserved nature in 2000, the amount of research into their function--particularly how they contribute to malignancy--has greatly increased. This class of small RNA molecules control gene expression and provide a previously unknown control mechanism for protein synthesis. As such, it is unsurprising that miRNAs are now known to play an essential part in malignancy, functioning as tumour suppressors and oncogenes. This Review summarises the present understanding of how miRNAs operate at the molecular level; how their dysregulation is a crucial part of tumour formation, maintenance, and metastasis; how they can be used as biomarkers for disease type and grade; and how miRNA-based treatments could be used for diverse types of malignancies.
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The lancet oncology · Jun 2012
Comparative StudyCancer incidence in patients with polyglutamine diseases: a population-based study in Sweden.
Polyglutamine (polyQ) diseases are characterised by the expansion of CAG triplet repeats in specific genes. The accumulated encoded proteins affect the transcription of numerous transcription factors. We investigated whether polyQ diseases reduce the risk of cancer development. ⋯ Swedish Cancer Society, Swedish Council for Working Life and Social Research.