The lancet oncology
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The lancet oncology · Sep 2012
Randomized Controlled Trial Multicenter Study Comparative StudyTemozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial.
Most patients with glioblastoma are older than 60 years, but treatment guidelines are based on trials in patients aged only up to 70 years. We did a randomised trial to assess the optimum palliative treatment in patients aged 60 years and older with glioblastoma. ⋯ Merck, Lion's Cancer Research Foundation, University of Umeå, and the Swedish Cancer Society.
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The lancet oncology · Sep 2012
Randomized Controlled TrialEffect of alternate-week versus continuous dexamethasone scheduling on the risk of osteonecrosis in paediatric patients with acute lymphoblastic leukaemia: results from the CCG-1961 randomised cohort trial.
Acute lymphoblastic leukaemia (ALL) is curable in more than 80% of children and adolescents who exhibit high-risk features. However, treatments are associated with symptomatic osteonecrosis that disproportionately affects adolescents. Based on the findings from the CCG-1882 trial, the CCG-1961 trial was designed to assess whether dexamethasone dose modification would reduce the risk of osteonecrosis. We therefore compared use of continuous versus alternate-week dexamethasone within standard and intensified post-induction treatments. ⋯ US National Cancer Institute at the National Institutes of Health.
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The lancet oncology · Sep 2012
Editorial CommentFirst do no harm: counting the cost of chasing drug efficacy.