The lancet oncology
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The lancet oncology · Jul 2022
Prognostic factors in curative intent stage I lung adenocarcinoma: a retrospective hospital-based cohort study.
Radiotherapy or surgery, depending on hospital specialisation status (ie, High Complexity Centres in Oncology [HCCO; hospitals with infrastructure, technology, physical facilities, equipment, and human resources suitable for highly complex specialised assistance], or Partial Hospital Complexity Centres in Oncology [PHCCO; hospitals with infrastructures and specialisation similar to that of HCCOs, but doing diagnosis and treatment for common cancers only], as per nomenclature used in Brazil), can increase overall survival in patients diagnosed with lung adenocarcinoma. However, many patients do not accept surgery because of comorbidities and personal preferences. In addition, the long time between diagnosis and treatment and the qualification of the hospital specialisation status might affect the outcomes for patients with lung adenocarcinoma. The aim of this study was to evaluate prognostic factors of overall survival in patients with stage I lung cancer adenocarcinoma diagnosed in the state of São Paulo, Brazil. ⋯ Oncocentro Foundation and Hospital Alemão Oswaldo Cruz, São Paulo, Brazil.
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The lancet oncology · Jul 2022
Association of tobacco control measures with the intention to quit tobacco consumption: a cross-sectional study from India.
More than 7 million cancer-related deaths worldwide are associated with tobacco, of which India is the second largest producer and consumer. The current study tests a model based on the hypothesis that poor implementation of tobacco control measures and poor basic education affect the frequency and duration of tobacco use, creating substantial nicotine dependency and thereby preventing smokers from quitting tobacco consumption. ⋯ None.
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The lancet oncology · Jul 2022
Impact of health insurance type on access to vaccination and mortality due to COVID-19 on patients with cancer in Colombia: a cohort study.
In Colombia, all paid workers earning minimum wage or higher contribute part of their salary for access to the national health-care system through a type of insurance called contributive plan, which supports the remaining low-income population that is enrolled on the subsidised plan. During the COVID-19 pandemic, Colombia documented high mortality rate in patients with cancer, with higher mortality among low-income patients, according to data from our national registry of COVID-19 infection in patients with cancer. The aim of this research was to establish the differential access to COVID-19 vaccination depending on health insurance type, and its impact on mortality due to COVID-19 infection. ⋯ None.
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The lancet oncology · Jul 2022
Induction-maintenance approach for the chronic phase of chronic myeloid leukaemia (IMPACT-I): a prospective, single-arm, phase 2 study.
Imatinib and second-generation tyrosine-kinase inhibitors (2G-TKIs) are standard options for the first-line treatment of chronic myeloid leukaemia. Although 2G-TKIs are superior to imatinib in terms of rate and depth of molecular response, they do not bring significant improvements in survival outcomes, and concerns exist over their long-term safety. The availability of a generic formulation makes imatinib an attractive economical option. We propose a novel induction-maintenance approach that would have the advantage of inducing early molecular response with 2G-TKIs, followed by maintenance with the safer and more affordable imatinib. ⋯ 2017 Young Investigator Research Grant from the Hong Kong College of Physicians.
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The lancet oncology · Jul 2022
Comprehensive characterisation of Lynch syndrome and screening strategies: a cohort study of individuals at risk from Latin American genetic registries.
Systematic screening for Lynch syndrome is non-existent in most Latin American countries. Until regional guidelines are developed and implemented, patients with colorectal cancer in Latin America are being followed up according to international recommendations. The aim of this study was to characterise the current Lynch syndrome screening method in the region, and to explore the prevalence of Lynch syndrome in a large cohort of individuals at risk. ⋯ Norwegian Cancer Society (contract 194751-2017).