The lancet oncology
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The lancet oncology · Jul 2022
Screening and eradication of Helicobacter pylori to prevent gastric cancer in indigenous Taiwanese communities: a population-based study and development of an index-case method.
Gastric cancer is one of the leading causes of cancer death, particularly in Asia and South America. Screening and eradication of Helicobacter pylori is recognised as an advantageous solution to reduce the disparities in the incidence of this cancer. However, the deployment of such policies is not yet sufficiently advanced in high-incidence areas. Our study aimed to show the acceptability and feasibility of an index-case method to implement a screening and eradication policy in high-risk populations living in Taiwanese indigenous communities. ⋯ Health Promotion Administration, Ministry of Health and Welfare, Taiwan (grant number A1101008).
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The lancet oncology · Jul 2022
Observational StudySalivary and tumour tissue miR-21 for prediction of cervical lymph node metastasis in patients with oral squamous cell carcinoma: an observational study.
Oral squamous cell carcinoma is a substantial health burden and one of the most common cancers worldwide. 40% of patients with oral squamous cell carcinoma have metastasis to cervical lymph nodes. Modern diagnostic aids for the assessment of lymph node metastasis have some limitations and drawbacks. miR-21 targets genes associated with the metastatic process in oral squamous cell carcinoma. The aim of the study was to evaluate the sensitivity and specificity of miR-21 for the assessment of cervical lymph node metastasis in patients with oral squamous cell carcinoma. ⋯ None.
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The lancet oncology · Jul 2022
Multimorbidity among patients with digestive cancers patients in Chile: a nationwide database study.
Multimorbidity, the presence of two or more chronic diseases in one individual, affects an increasing number of patients worldwide, creating one of the main challenges in global public health. Multimorbidity results in higher mortality, lower quality of life, and individual risks, such as polypharmacy and exposure to complex therapeutic regimens. In Chile, five of the top ten cancers with the highest mortality rates affect the digestive system. To our knowledge, this is the first study based on a national-wide database focused on multimorbidity in patients with cancer in Chile. Our objective was to characterise multimorbidity and establish the chronic diseases and combinations thereof that most contribute to multimorbidity in patients with digestive cancers in Chile. ⋯ National Agency for Research and Development (reference 21210439).