The lancet oncology
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The lancet oncology · Jul 2022
Prognostic factors in curative intent stage I lung adenocarcinoma: a retrospective hospital-based cohort study.
Radiotherapy or surgery, depending on hospital specialisation status (ie, High Complexity Centres in Oncology [HCCO; hospitals with infrastructure, technology, physical facilities, equipment, and human resources suitable for highly complex specialised assistance], or Partial Hospital Complexity Centres in Oncology [PHCCO; hospitals with infrastructures and specialisation similar to that of HCCOs, but doing diagnosis and treatment for common cancers only], as per nomenclature used in Brazil), can increase overall survival in patients diagnosed with lung adenocarcinoma. However, many patients do not accept surgery because of comorbidities and personal preferences. In addition, the long time between diagnosis and treatment and the qualification of the hospital specialisation status might affect the outcomes for patients with lung adenocarcinoma. The aim of this study was to evaluate prognostic factors of overall survival in patients with stage I lung cancer adenocarcinoma diagnosed in the state of São Paulo, Brazil. ⋯ Oncocentro Foundation and Hospital Alemão Oswaldo Cruz, São Paulo, Brazil.
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The lancet oncology · Jul 2022
APC mutations as a predictive marker of endometrial cancer immunotherapy: a retrospective cohort study.
The APC regulator of WNT signalling pathway gene (previously known as adenomatous polyposis coli gene; APC), located on 5q22.2, is a chromatin remodelling-related gene and a typical tumour suppressor. Patients with high expression of PD-L1 or a high tumour mutational burden have been reported to benefit from immunotherapy in endometrial cancer. The objective of this study was to show that APC is a new biomarker target for the diagnosis and treatment of endometrial cancer by analysing the correlation of APC mutations with PD-L1 expression or tumour mutational burden. ⋯ The study was supported by the National Natural Science Foundation of China (grant numbers 81472427, 32070583, 81672574, and 81702547), the Shanghai Health System Outstanding Talents Program (grant number 2018YQ23), the Shanghai New Frontier Technology Project (grant number SHDC12015110), and the Shanghai Municipal Medical and Health Discipline Construction Projects (grant number 2017ZZ02015).
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The lancet oncology · Jul 2022
Factors affecting acceptance of palliative care in mainland China: a national cross-sectional study.
China ranks 53rd in the list of 81 countries included in the Quality of Death and Dying Index 2021. Cancer is one of the leading causes of death in China. Although the country is highly burdened with cancer, with 4·5 million new diagnoses and more than 3 million cancer deaths in 2020 alone, palliative care services in mainland China are extremely scarce. The aim of this study was to investigate the attitudes of people towards palliative and hospice care, and to analyse the associations between attitudes and potential explanatory variables. ⋯ The scientific research project of Shaanxi Provincial Education Department, 2021 (grant 21JZ017), and Youth Project of Key Research Bases of Philosophy and Social Sciences in the Sichuan Province (grant YF22-Q13).
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The lancet oncology · Jul 2022
Epidemiology and outcomes of acute promyelocytic leukaemia in the era of all-trans retinoic acid: a retrospective analysis.
Acute promyelocytic leukaemia (APL) results from the reciprocal chromosomal translocation t(15;17)(q24;21) (PML-RARA gene fusion). We have formulated an oral, economical, and outpatient-based preparation of arsenic trioxide and shown that it is efficacious for newly diagnosed and relapsed APL. In this study, we aimed to define the epidemiological landscape of APL in Hong Kong and to assess the effect of oral arsenic trioxide therapy on patient outcomes. ⋯ Health and Medical Research Fund of the Hong Kong Special Administrative Region, China (code 08191946).
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The lancet oncology · Jul 2022
Feasibility of human papillomavirus self-sampling to combat COVID-19-related disruptions to cervical cancer screening: a cross-sectional survey.
The prevalence of human papillomavirus (HPV) infection among Chinese women in Hong Kong has been reported to range between 7% and 11%, and high-risk HPV genotypes accounted for about 90% of cases of cervical cancer. The COVID-19 pandemic has had a major impact on a wide range of health outcomes because of limitations to the functioning of health services, including cervical cancer screening. The aim of this study was to assess HPV self-sampling as an alternative option for cervical cancer screening during the COVID-19 pandemic. ⋯ This study was supported by the Commissioned Health and Medical Research Fund of Food and Health Bureau of HKSAR Government (reference number CID-CUHK-E).