Heart, lung & circulation
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Heart, lung & circulation · May 2016
Randomized Controlled Trial Multicenter StudyPulmonary Protective Effects of Remote Ischaemic Preconditioning with Postconditioning in Patients undergoing Cardiac Surgery involving Cardiopulmonary Bypass: A substudy of the Remote Ischaemic Preconditioning with Postconditioning Outcome trial.
The RISPO (Remote Ischemic Preconditioning with Postconditioning Outcome) trial evaluated whether remote ischaemic preconditioning (RIPC) combined with remote ischaemic postconditioning (RIPostC) improves the clinical outcomes of patients undergoing cardiac surgery. This substudy of the RISPO trial aimed to evaluate the effect of RIPC with RIPostC on pulmonary function in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). ⋯ In our study, RIPC-RIPostC improved the post-operative 24h PaO2/FIO2 ratio. Remote ischaemic preconditioning-Remote ischaemic postconditioning has limited and delayed pulmonary protective effects in cardiac surgery patients with CPB.