International immunopharmacology
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Int. Immunopharmacol. · Dec 2014
Randomized Controlled TrialGabapentin-induced changes of plasma cortisol level and immune status in hysterectomized women.
We have examined the effects of gabapentin (GBP) on stress-related changes of cortisol and catecholamines in patients who underwent hysterectomy because of uterine fibrinoids. Additionally, we have observed the effect of GBP on the immune status in the acute stress response to surgery. ⋯ Preoperative administration of GBP reduced the pain scores at rest in patients at 0, 16 and 24h after abdominal hysterectomy. Additionally, GBP reduced the stress response and changed immune parameters in the reaction to surgery.