Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
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Practice Guideline
IAP/APA evidence-based guidelines for the management of acute pancreatitis.
There have been substantial improvements in the management of acute pancreatitis since the publication of the International Association of Pancreatology (IAP) treatment guidelines in 2002. A collaboration of the IAP and the American Pancreatic Association (APA) was undertaken to revise these guidelines using an evidence-based approach. ⋯ The 2012 IAP/APA guidelines provide recommendations concerning key aspects of medical and surgical management of acute pancreatitis based on the currently available evidence. These recommendations should serve as a reference standard for current management and guide future clinical research on acute pancreatitis.
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To assess the efficiency and safety of parenteral analgesics for pain relief in acute pancreatitis. ⋯ The systemic review showed that the randomized controlled trials comparing different analgesics were of low quality and did not favor clearly any particular analgesic for pain relief in acute pancreatitis.
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Circulating polymorphonuclear leukocytes (PMNLs) may contribute to development of organ dysfunction in acute pancreatitis (AP). We outlined aberrations in PMNL signaling profiles in patients with AP complicated by organ dysfunction and immune suppression. ⋯ In patients with AP complicated by organ dysfunction proportion of pNFκB-positive PMNLs is decreased. This impairs patients' defense mechanisms against infection. Despite immune suppression, PMNL transmigration was increased and p38 phosphorylation capacity was not depressed, which may contribute to end organ inflammation and dysfunction.
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The number of times an article is cited in scientific journals reflects its impact on a specific biomedical field or specialty and reflects the impact of the authors' creativity. Our purpose was to characterize the most frequently cited articles about acute pancreatitis. ⋯ "Citation classics" about acute pancreatitis are detected in both experimental and clinical research field, which provide a historical perspective on the scientific progress and allow for recognition of important advances in this specialty.
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Comparative Study
Correlation between procalcitonin and intra-abdominal pressure and their role in prediction of the severity of acute pancreatitis.
Early assessment of disease severity and vigilant patient monitoring are key factors for adequate treatment of acute pancreatitis (AP). The aim of this study was to determine the correlation of procalcitonin (PCT) serum concentrations and intra-abdominal pressure (IAP) as prognostic markers in early stages of AP. ⋯ Increased IAP was accompanied by increased PCT serum concentration in patients with AP. PCT and IAP can both be used as early markers of AP severity.