Perspectives in vascular surgery and endovascular therapy
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Perspect Vasc Surg Endovasc Ther · Mar 2012
ReviewEpidermal growth factor in the treatment of diabetic foot ulcers: an update.
Management of diabetic foot ulcers remains a rather challenging task. Epidermal growth factor (EGF) plays a central role in wound healing. It acts on epithelial cells and fibroblasts promoting restoration of damaged epithelium. ⋯ Generally, adverse events have been minor to mild. Finally, numerous issues need to be further clarified before widespread use of EGF becomes possible in everyday practice. Such issues include optimal dosage and administration route, characteristics of the ulcers most likely to heal (severity and ischemic/neuropathic or both), and cost-effectiveness.