Acta dermato-venereologica. Supplementum
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Acta Derm Venereol Suppl (Stockh) · Jan 1992
Randomized Controlled Trial Comparative Study Clinical TrialComparative effects of two topical antiseptics (chlorhexidine vs KMn04) on bacterial skin flora in atopic dermatitis.
In order to determine the efficacy and tolerance of two topical antiseptics, chlorhexidine vs KMn04 (diluted at 1:20,000), we compared their bacteriological and clinical effects in a randomized trial on 20 children with Atopic Dermatitis (AD) treated with topical steroids (desonide). After treatment, a clinical improvement was noted in the two groups, though without statistical differences. In vivo: Before treatment, Staphylococcus aureus (S. ⋯ A. was greater in the chlorhexidine group than in the KMn04 group, without significant difference. In vitro: At the clinical dilution used, there was a statistical difference (p < 0.05) between the number of killed bacteria in the chlorhexidine group (-3 log) and the number in the KMn04 group (-1 log). This study confirms the role and importance of the choice of a topical antiseptic in the treatment of AD.
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Acta Derm Venereol Suppl (Stockh) · Jan 1991
Randomized Controlled Trial Clinical TrialItch and atopic dermatitis: clinical and experimental studies.
The aims of the study were to develop and evaluate methods for quantitative measurement of itch, to investigate the perception of itch in patients with atopic dermatitis (AD), and to measure itch in such patients during treatment with H1-receptor antagonists or cyclosporin A, thereby exploring possible mechanisms in the pathogenesis of itch in AD. In a double-blind, randomized, placebo-controlled, cross-over study of 30 AD patients using a potent, topical, antipruritic corticosteroid, two methods for measuring itch both successfully detected the itch-relieving effect of the corticosteroid. The two methods comprised new portable data-loggers (Pain-Track) for continuous recording of itch, and conventional visual analogue scale (VAS) forms for retrospective recording. ⋯ In a double-blind, randomized, placebo-controlled, cross-over study of 25 AD patients, the effect on clinical itch of a sedative (clemastine) and of a non-sedative (terfenadine) antihistamine did not differ from that of placebo, although both drugs had a pronounced H1-receptor-antagonizing effect in the skin and clemastine was significantly sedative. These findings support the view that histamine is not the major pruritogen in AD, and that sedation is not necessarily associated with itch relief. In a double-blind, randomized, placebo-controlled, cross-over study of 10 AD patients, 10 days' treatment with cyclosporin A (CSA), 5 mg/kg/day, significantly reduced itch intensity, eczema score and the number of peripheral blood eosinophils.(ABSTRACT TRUNCATED AT 400 WORDS)
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Acta Derm Venereol Suppl (Stockh) · Jan 1990
Randomized Controlled Trial Comparative Study Clinical TrialStudies on zinc in wound healing.
Topical zinc is widely used in wound treatment although the beneficial effect of zinc has only been documented in zinc-deficient patients who were given zinc orally. The main purpose of this study was to investigate the effect of topically applied zinc on leg ulcer healing and examine its effect on some mechanisms in wound healing using standardized animal models. Additionally, absorption of zinc into wounds and intact skin treated topically with zinc was studied. ⋯ Zinc absorption in and through normal human forearm skin was demonstrated after treatment with a zinc oxide medicated occlusive dressing by increased zinc levels in epidermis, interstitial fluid and dermis compared with the non-zinc control dressing. In conclusion, topical zinc may stimulate leg ulcer healing by enhancing re-epithelialization, decreasing inflammation and bacterial growth. When zinc is applied on wounds it not only corrects a local zinc deficit but also acts pharmacologically.(ABSTRACT TRUNCATED AT 400 WORDS)