ANZ journal of surgery
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ANZ journal of surgery · Sep 2009
Review Meta Analysis Comparative StudyLinezolid versus vancomycin for MRSA skin and soft tissue infections (systematic review and meta-analysis).
This review aims to compare the effectiveness of linezolid to vancomycin for the treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) skin and soft tissue infections (SSTIs) in inpatients. ⋯ With the current available data no difference could be detected between the two treatments, but a trend towards higher effectiveness of linezolid was observed. More data will be required to determine if linezolid is superior to vancomycin for the treatment of MRSA SSTIs. Further systematic reviews are needed to look at other outcomes (length of hospital stay, safety and tolerability, cost-effectiveness) and at MRSA infections at other sites.