ANZ journal of surgery
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ANZ journal of surgery · Dec 2013
Review Meta AnalysisEffectiveness of massive transfusion protocols on mortality in trauma: a systematic review and meta-analysis.
The effectiveness of massive transfusion protocols (MTPs) has been assumed from low quality studies with multiple biases. This review aimed to (i) evaluate the association between the institution of an MTP and mortality and (ii) determine the effect of MTPs on transfusion practice post trauma. ⋯ Despite the popularity of MTPs and directives mandating their use in trauma centres, in before-after studies, MTPs have not always been associated with improved mortality. Evidence-based standardization of MTPs, improved compliance and analysis of broader endpoints were identified as areas for further research.