The journal of family planning and reproductive health care
-
J Fam Plann Reprod Health Care · Jan 2002
Randomized Controlled TrialPrevention of migraine in the pill-free interval of combined oral contraceptives: a double-blind, placebo-controlled pilot study using natural oestrogen supplements.
Migraine in the pill-free interval of combined oral contraceptives is reported by many women, but there is little published information on possible mechanisms and treatments. ⋯ The results of this pilot study suggest that use of 50 microg oestrogen patches during the pill-free interval may reduce the frequency and severity of migraine at that time. This study should be repeated with larger numbers of women and a higher dose of oestrogen.