Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology
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Randomized Controlled Trial
A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis.
Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA is loss of cartilage; however, it is evident that the rate of cartilage loss differs among patients, which may partly be attributed to differential capacity for cartilage repair. We hypothesize that a low cartilage repair endotype exists and that such endotypes are more likely to progress radiographically. The aim of this study is to examine the associations of level of cartilage formation with OA severity and radiographic OA progression. We used the blood-based marker PRO-C2, reflecting type II collagen formation, to assess levels of cartilage formation. ⋯ Level III post hoc exploratory analysis of one longitudinal cohort and a sub-study from one phase III clinical trial.