Internal medicine journal
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Internal medicine journal · May 2021
Meta AnalysisFebuxostat as a renoprotective agent for treatment of hyperuricaemia: a meta-analysis of randomised controlled trials.
The objective of this meta-analysis of randomised controlled clinical trials (RCT) was to evaluate the effects of febuxostat on kidney function in patients with hyperuricaemia. ⋯ Treating hyperuricaemia with febuxostat may slow the progression of chronic kidney disease irrespective of baseline renal function without significantly associated increased risks of major cardiovascular events, diarrhoea, joint symptoms, arrhythmia and stroke, compared to placebo.
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Internal medicine journal · May 2021
ReviewEnergy Drinks: A Narrative Review Of Their Physiological And Pathological Effects.
The consumption of energy drinks (Edks) has increased significantly in past years, with a growing market that is estimated to reach $61 billion by 2021 worldwide. Several studies demonstrated the physiological and pathological effects of these substances contained in Edks. The most common ingredient contained in Edks is caffeine, which is commonly mixed with taurine, and B-group vitamins. ⋯ We found a significant focus on arrhythmogenic risk in patients affected by long QT syndrome or other predisposing conditions for QT elongation. Other pathological effects are known as gastrointestinal, vascular and neurological disorders. Edks, as well as all caffeinated beverages, should be taken with caution or avoided in select populations, such as patients suffering from cardiovascular or neurological illnesses; their use can unmask a sleepy life-threatening disease.
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Internal medicine journal · May 2021
Health Status and Health Care Trends of Individuals Accessing Australian Aged Care Programs Over a Decade: The Registry of Senior Australians (ROSA) Historical Cohort.
Understanding the health profile, service and medicine use of Australians in the aged care sector will help inform appropriate service provision for our ageing population. ⋯ The health of older Australians accessing aged care programmes has declined while frailty increased, with an increasing use of medicine and worse long-term mortality in some. Funding and care models need to adapt to this changing profile.
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Internal medicine journal · May 2021
The Oxygen project: a prospective study to assess the effectiveness of a targeted intervention to improve oxygen management in hospitalised patients.
Oxygen is commonly used in the acute care setting. However, used inappropriately, oxygen therapy can result in adverse consequences, including progressive respiratory failure and death. ⋯ The education programme intervention to improve oxygen prescription showed promise in the medical wards but did not impact outcomes in the surgical ward setting, where different strategies may be needed.
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Internal medicine journal · May 2021
Long-term outcomes in patients with pulmonary embolism: results from a longitudinal cohort study.
Patients with pulmonary embolism (PE) have increased mortality in short-term; however, long-term prognosis is not well defined. ⋯ In this prospective study, we did not find association between PE and risk of all-cause mortality or SCE. Major determinants of poor clinical outcomes were advancing age and underlying comorbidities.