Transplantation
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The metabolic processes occurring within the preserved kidney during hypothermic machine perfusion (HMP) are not well characterized. The aim of this study was to use nuclear magnetic resonance (NMR) spectroscopy to examine the metabolomic profile of HMP perfusate from human cadaveric kidneys awaiting transplantation and to identify possible discriminators between the profiles of kidneys with delayed graft function (DGF) and immediate graft function (IGF). ⋯ Significant metabolic activity may be occurring in kidneys during HMP. The NMR spectroscopy of the perfusate can identify differences in the metabolomic profiles of DGF and IGF kidneys that might have a predictive role in viability assessment. Modification of harmful metabolic processes may improve outcomes for HMP kidneys.
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Awareness among the medical students and junior doctors about organ donation and transplantation (ODT) may play an important role in increasing organ donor pool. This study surveys the knowledge, perceptions, and attitudes of ODT among the U.K. junior doctors and attempts to identify their educational needs. To our knowledge, this is first such study in the United Kingdom. ⋯ Junior doctors in the United Kingdom have limited knowledge about ODT. Although subjected to investigators bias, the results demonstrate that junior doctors' perceptions and attitudes toward ODT were favorable. Majority felt that their ODT knowledge was inadequate and suggested the need for a change in undergraduate ODT curriculum. Increasing knowledge and awareness among junior doctors may help to improve the continuing organ shortage for transplantation.
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Editorial Biography Historical Article
Sir Peter J. Morris, AC, FRS: Melbourne and Oxford Universities' transplantation surgeon and retiring editor of Transplantation, 1976-2014.