Best practice & research. Clinical anaesthesiology
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Best Pract Res Clin Anaesthesiol · Sep 2005
ReviewNitrous oxide: a unique drug of continuing importance for anaesthesia.
Early attempts to use nitrous oxide as a sole anaesthetic foundered because of its low potency. It has been used successfully as an adjunct to more potent anaesthetics, however, since 1868. By enabling reduced doses of more potent anaesthetics, nitrous oxide reduces the cost of anaesthesia and limits cardiorespiratory side effects. ⋯ Perhaps the greatest argument for the continued use of nitrous oxide is that it reduces the incidence of recall of intraoperative awareness. Reduced pharmacokinetic variability compared with other anaesthetics, especially intravenous agents, is likely to be a most important reason for this, although evidence is emerging that nitrous oxide also has pharmacodynamic advantages. There are specific situations in which nitrous oxide should not be used, but in the absence of these, its use can be favourably recommended.
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Best Pract Res Clin Anaesthesiol · Sep 2005
Review Historical ArticleInhaled anesthetics: an historical overview.
Inhalational agents have played a pivotal role in anesthesia history. The first publicly demonstrated anesthetic of the modern era, diethyl ether, was an inhalational anesthetic. The attributes of a good agent, ability to rapidly induce anesthesia, with limited side effects has led research efforts for over a hundred and fifty years. ⋯ Rapid emergence, with limited nausea and vomiting continue to drive discovery efforts, yet the 'modern' agents continue to improve upon those in the past. The future holds promise, but perhaps the most interesting contrast over time is the ability to rapidly introduce new agents into practice. From James Young Simpson's dinner table one evening to the operating suite the next day, modern agents take decades from first synthesis to clinical introduction.
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Best Pract Res Clin Anaesthesiol · Sep 2005
ReviewNew and alternative delivery concepts and techniques.
The suitability of any method of delivering anaesthetic vapours to the breathing system can be judged only if seen in relation to the fresh gas flow. Due to its advantage in essentially reducing anaesthetic gas and vapour consumption, low-flow anaesthesia has become the acknowledged method of performing inhalational anaesthesia. Conventional plenum vaporizers, connected to the fresh gas supply, meet all technical needs for efficient, safe and simple performance of low-flow and minimal-flow anaesthesia. ⋯ The injection of liquid anaesthetics into the breathing system with the aid of a motor syringe seems most promising; however, such a technique is not approved, and in its simple version contravenes several regulations of the technical norm. Closed-loop feedback control of metering anaesthetic gases and vapours, as realized in the PhysioFlex and ZEUS anaesthetic workstations, allows the realization of 'quantitative closed-system anaesthesia' in clinical practice. If complex anaesthetic gas compositions are used, including for instance nitrous oxide, closed-system anaesthesia can be performed in clinical practice only with such sophisticated machines.
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Best Pract Res Clin Anaesthesiol · Sep 2005
ReviewThe concept of anaesthetic-induced cardioprotection: clinical relevance.
Experimental evidence has clearly demonstrated that volatile anaesthetic agents have direct protective properties against reversible and irreversible ischaemic myocardial damage. These properties have been related to a direct preconditioning effect but also to an effect on the extent of reperfusion injury. ⋯ This potential application of anaesthetic agents has only recently been explored, and its applicability in clinical practice is the subject of ongoing research. This review summarizes the current knowledge on this subject.
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An 'ideal' anaesthetic can be approached by using a combination of different compounds. A variety of anaesthetic techniques has been described to ensure safe administration and an early recovery with high patient satisfaction. In particular, the inhalational anaesthetics desflurane and sevoflurane, with their rapid pharmacokinetics, re-established the notion of balanced anaesthesia as an equivalent, well-controllable technique. With the choice of anaesthetics and anaesthetic adjuvants clinically available today, especially the combination of a volatile anaesthetic with a short-acting opioid, balanced anaesthesia represents a big step towards an ideal anaesthetic.