Revista de saúde pública
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Revista de saúde pública · Jun 2005
Randomized Controlled Trial Comparative StudyReactogenicity of yellow fever vaccines in a randomized, placebo-controlled trial.
To compare the reactogenicity of three yellow fever (YF) vaccines from WHO-17D and Brazilian 17DD substrains (different seed-lots) and placebo. ⋯ The frequency of adverse events post-immunization against YF, accounting for the background occurrence of nonspecific signs and symptoms, was shown for the first time to be similar for vaccines from 17D and 17DD substrains. The data also provided evidence against viscerotropism of vaccine virus.