Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
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Multicenter Study Comparative Study
Asians with cystic fibrosis in the UK have worse disease outcomes than clinic matched white homozygous delta F508 controls.
We tested the hypothesis that the Asian cystic fibrosis (CF) phenotype is comparable to the commonest genetic form of CF found in 50% of the white UK CF population using the UK CF Database, a national disease-specific patient registry. ⋯ These data suggest that the Asian CF phenotype is as severe as the white controls with the homozygous delta F508 phenotype but is worse in some outcomes, especially in Asian females. Socio-cultural factors and rare CF genotypes may contribute to the severity of CF in this vulnerable group.