Latest Articles
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Cochrane Db Syst Rev · Jan 2025
Review Meta AnalysisThrombolysis for aneurysmal subarachnoid haemorrhage.
Aneurysmal subarachnoid haemorrhage continues to cause a significant burden of morbidity and mortality despite advances in care. Trials investigating local administration of thrombolytics have reported promising results. ⋯ There is some evidence that thrombolysis can probably improve outcomes after aneurysmal subarachnoid haemorrhage, without increasing the risk of haemorrhagic complications. Thrombolysis likely reduces the risk of poor functional outcome and cerebral artery vasospasm, and may reduce the risk of delayed cerebral ischaemia, but it likely makes little to no difference to case fatality or hydrocephalus, and may make little to no difference to the risk of cerebral infarction. However, the current evidence is still uncertain. The uncertainty is primarily due to the small total number of participants and outcome events. Data from further studies are required to confirm the efficacy of thrombolysis for improving outcomes after aneurysmal subarachnoid haemorrhage.
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This study aimed to investigate the effect of incentive nursing care (ICN) as a supplementary therapy to routine nursing care (RNC) on depression and anxiety (DA) in patients undergoing thyroid cancer (TC) surgery during the perioperative period (PPP). ⋯ The findings of this study demonstrate the considerable benefits of implementing ICN and RNC in the management of DA among patients with TC during PPP. However, it is crucial to interpret these results cautiously in light of the aforementioned limitations.
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Meta Analysis Comparative Study
Comparison of TPF and PF induction chemotherapy combined with cisplatin concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: A systematic review and meta-analysis.
The standard of care for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) is induction chemotherapy (ICT) followed by concurrent chemoradiation (CCRT). However, the ideal ICT regimen for LA-NPC remains unclear. We conducted a meta-analysis to evaluate the survival outcomes, responses, and incidences of toxicities between taxane, cisplatin and fluorouracil (TPF) and cisplatin and fluorouracil (PF) ICT regimens plus CCRT in LA-NPC. ⋯ In terms of progression-free survival, overall survival, locoregional recurrence-free survival, in the era of intensity-modulated radiotherapy, the TPF plus CCRT with cisplatin is superior to PF plus CCRT with cisplatin in LA-NPC. Thus, the TPF plus CCRT regimen appears to be a reasonable treatment option, and further confirmation by prospective studies is needed.
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Due to the lack of a prior comprehensive review and meta-analysis, the relationship between monocyte count and thrombus load in ST-elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI) has not been adequately established. ⋯ STEMI patients with a high thrombus burden show an increased monocyte count. A high monocyte count upon admission is a major indication of increased intracoronary thrombus burden in STEMI patients with PCI procedures.
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The Epley or Semont maneuver is performed for posterior canal benign paroxysmal positional vertigo (PC-BPPV). The postural crisis indicates the phenomenon that the patient experiences severe dizziness, is unable to maintain the sitting posture, and suddenly falls backward or sideways on the examination table when returning to the sitting position, which is the final step of the canalith repositioning procedure (CRP). The postural crisis increases the risk of falls during CRP. This meta-analysis aimed to determine the incidence of postural crisis among patients who underwent CRP for PC-BPPV. ⋯ BPPV is the most common among peripheral vestibular diseases, usually occurring in the posterior semicircular canal. Therefore, 10% of cases with CRP for PC-BPPV is significant. When performing CRP for PC-BPPV, considering that the postural crisis related to increasing the risk of falls may occur, preparations for the phenomenon should be made in advance.