Articles: analgesics.
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Acta Anaesthesiol. Sin. · Jun 1996
Randomized Controlled Trial Clinical Trial[Pre- and intra-operative administration of epidural morphine provides good postoperative pain relief after laminectomy].
To evaluate the postoperative analgesic effect of epidural morphine administered at different timing in lumbar spine surgery. ⋯ Preoperative or intraoperative administration of epidural morphine could provide satisfactory analgesia in lumbar spine surgery during the first 24 h postoperatively.
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British dental journal · May 1996
Randomized Controlled Trial Comparative Study Clinical TrialA double-blind placebo-controlled study to assess the efficacy of a compound analgesic to prevent postoperative pain following oral surgery.
It has been suggested that small doses of opioid drugs given prior to surgery can reduce postoperative pain. This study was designed to compare the effectiveness of a paracetamol/codeine combination and paracetamol alone in preventing the pain following surgical removal of impacted third molar teeth under general anaesthesia. Analysis of the results showed no statistical differences between treatment groups when compared with placebo. We suggest that the opioids may not be the best drugs available to prevent the moderate to severe pain present following some oral surgery procedures.
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J Bone Joint Surg Am · May 1996
Randomized Controlled Trial Clinical TrialIntra-articular injection of bupivacaine in knee-replacement operations. Results of use for analgesia and for preemptive blockade.
The effectiveness of an intra-articular injection of bupivacaine, administered before the incision or after closure of the wound, was studied in an effort to decrease the need for postoperative narcotics and to improve analgesia for patients who have elective knee replacement. Eighty-two patients received two intra-articular injections in a random, double blind fashion. Twenty-eight of them received thirty milliliters of 0.5 percent bupivacaine and 1:200,000 epinephrine in saline solution before the incision and an injection of thirty milliliters of plain saline solution after closure of the wound (Group 1). ⋯ Serum concentrations of bupivacaine were well below toxic levels. It was our conclusion that that and intra-articular injection of thirty milliliters of 0.5 percent bupivacaine and 1:200,000 epinephrine in saline solution after closure of the wound decreases the need for narcotics and increases the range of motion after an elective knee replacement. The clinical importance of the amount of increased motion is questionable and needs long-term monitoring.
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Randomized Controlled Trial Clinical Trial
Ketorolac does not decrease postoperative pain in elderly men after transvesical prostatectomy.
To assess the postoperative analgesic efficacy and morphine-sparing effect of ketorolac in elderly patients. ⋯ The intraoperative administration of ketorolac, 60 mg, im, was not associated with postoperative morphinesparing or improved analgesia in this elderly population.
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Acta Anaesthesiol Scand · May 1996
Randomized Controlled Trial Clinical TrialPatient-controlled analgesia with morphine and droperidol following caesarean section under spinal anaesthesia.
The addition of droperidol to morphine for patient-controlled analgesia reduces the incidence of nausea and vomiting, but may result in unwanted side effects. ⋯ The addition of droperidol 10 mg to morphine 60 mg for PCA following caesarean section under spinal anaesthesia reduces the incidence of nausea and emesis, but may result in drowsiness, limiting the usefulness of the technique.